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【结 构 式】 
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【药物名称】Technetium (99mTc) exametazime, [99mTc]-HMPAO, HMPAO-[99mTc], Ceretec 【化学名称】[[(±)-(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium-99Tc 【CA登记号】100551-63-1 (ligand), 105613-48-7 (ligand no stereoch.), 100504-35-6 (undefined stereoch.) 【 分 子 式 】C13H25N4O3Tc 【 分 子 量 】384.3692 |
【开发单位】Amersham (Originator) 【药理作用】DIAGNOSTIC AGENTS |
合成路线1
Condensation of 2,3-butanedione monooxime (I) with 2,2,-dimethyl-1,3-propanediamine (II) affords the bis-imine adduct (III). Subsequent reduction of the imine functions of (III) using NaBH4 in EtOH gives rise to a mixture of the meso-diamine (IV) and the racemic d,l-isomers (V). Separation of this mixture is achieved by either HPLC or fractional crystallization from acetonitrile and then from ethyl acetate. The target 99mtechnetium complex is prepared in situ by reduction of a solution of 99mTc-pertechnetate with stannous tartrate in the presence of the diamino dioxime ligand (V).
| 【1】 Nowotnik, D.P.; et al.; Development of a 99Tcm-labelled radiopharmaceutical for cerebral blood flow imaging. Nucl Med Commun 1985, 6, 9, 499. |
| 【2】 Nowotnik, D.P.; et al.; Separation of the stereoisomers of hexamethyl-propyleneamine oxime (HM-PAO) by high-performance liquid chromatography. J Liq Chromatogr 1995, 18, 4, 673. |
| 【3】 Nowotnik, D.P.; Canning, L.R.; Neirinckx, R.D.; Piper, I.M. (Amersham plc); Complexes of technetium-99m with propylene amine oximes. EP 0194843; JP 1986225159; US 4789736 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55397 | 2,3-Butanedione 2-oxime; 2,3-Butanedione monoxime; 2,3-Butanedione oxime; 2,3-Butanedione-2-monoxime; Diacetyl monoxime | 57-71-6 | C4H7NO2 | 详情 | 详情 |
| (II) | 56839 | 1,3-Diamino-2,2-dimethylpropane; Neopentandiamine | 7328-91-8 | C5H14N2 | 详情 | 详情 |
| (III) | 56840 | 3-[(3-{[(E)-2-(hydroxyimino)-1-methylpropylidene]amino}-2,2-dimethylpropyl)imino]-2-butanone oxime | C13H24N4O2 | 详情 | 详情 | |
| (IV) | 56841 | (3S)-3-[(3-{[(1R)-2-(hydroxyimino)-1-methylpropyl]amino}-2,2-dimethylpropyl)amino]-2-butanone oxime | C13H28N4O2 | 详情 | 详情 | |
| (V) | 56842 | (3R)-3-[(3-{[(1R)-2-(hydroxyimino)-1-methylpropyl]amino}-2,2-dimethylpropyl)amino]-2-butanone oxime | C13H28N4O2 | 详情 | 详情 |