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【结 构 式】 
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【药物名称】Troxipide, KU-54, Aplace 【化学名称】(±)-3-(3,4,5-Trimethoxybenzamido)piperidine 【CA登记号】30751-05-4 【 分 子 式 】C15H22N2O4 【 分 子 量 】294.35359 |
【开发单位】Kyorin (Originator) 【药理作用】Antiulcer Drugs, GASTROINTESTINAL DRUGS |
合成路线1
The condensation of 3,4,5-trimethoxybenzoyl chloride (I) with 3-aminopyridine (II) by means of pyridine in benzene gives 3-(3,4,5-trimethoxybenzamido)pyridine (III), which is hydrogenated with H2 over Pd/C in ethanol-water-HCl.
| 【1】 Irikura, T.; et al.; Benzoylamino substituted 1-benzoylpiperidines. US 3647805 . |
| 【2】 Irikura, T.; Kasuga, K.; New antiulcer agents. 1. Syntheses and biological activities of 1-acyl-2-, -3- and -4-substituted benzamidopiperidines. J Med Chem 1971, 14, 4, 357-361. |
| 【3】 Blancafort, P.; Castaner, J.; Dharma, A.P.; Serradell, M.N.; KU-54. Drugs Fut 1979, 4, 12, 882. |
Extended Information