|
【结 构 式】 
|
【药物名称】Troquidazole, EGIS-4136 【化学名称】N-(3-Nitro-4-quinolinyl)-4-morpholinecarboxamidine 【CA登记号】108001-60-1, 108001-71-4 (HCl) 【 分 子 式 】C14H15N5O3 【 分 子 量 】301.30735 |
【开发单位】Egis (Originator) 【药理作用】ONCOLYTIC DRUGS, Radiation Therapy, Radiosensitizers |
合成路线1
Nitroacetaldehyde oxime (I) is formed from nitromethane in the presence of NaOH and is converted in acidic media with 2-aminobenzoic acid (II) to 2-(2-nitroethylideneamino)benzoic acid (III). Cyclization of (III) in acetic anhydride by means of potassium acetate yields 4-hydroxy-3-nitroquinoline (IV), which is converted to 4-chloro-3-nitroquinoline (V) in boiling POCl3. Reaction of (V) with morpholinecarboximidamide (VIII) (formed from morpholine (VI) and S-methylisothiourea hemisulfate (VII) in ethanol) affords troquidazole.
| 【1】 Berényi, E.; Varga, L.; Pallos, L.; Petöcz, L.; Ladányi, L.; Tömpe, P.; Hartai, E.; Kovács, A. (Egis Pharmaceuticals Ltd.); N-(3-Nitroquinolin-4-yl)guanidine derivatives as radiosensitizers. (EGIS Pharm., Ltd.). BE 0904864; CH 668069; ES 8707231; GB 2176185; JP 1987048668; US 4652562 . |
| 【2】 Nógrádi, M.; Berényi, E.; Blaskó, G.; Troquidazole. Drugs Fut 1992, 17, 5, 384. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11660 | 2-Nitroacetaldehyde oximesodium salt | C2H3N2NaO3 | 详情 | 详情 | |
| (II) | 11661 | 2-Aminobenzoic acid;Anthranilic acid; o-Aminobenzoic acid | 118-92-3 | C7H7NO2 | 详情 | 详情 |
| (III) | 11662 | 2-[[(E)-2-Nitroethylidene]amino]benzoic acid | C9H8N2O4 | 详情 | 详情 | |
| (IV) | 11663 | 3-Nitro-4-quinolinol; 3-Nitro-quinolin-4-ol | C9H6N2O3 | 详情 | 详情 | |
| (V) | 11664 | 4-Chloro-3-nitroquinoline | C9H5ClN2O2 | 详情 | 详情 | |
| (VI) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
| (VII) | 10272 | [[Amino(imino)methyl]sulfanyl]methane | 2986-19-8 | C2H6N2S | 详情 | 详情 |
| (VIII) | 11667 | 4-Morpholinecarboximidamide | C5H11N3O | 详情 | 详情 |