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【结 构 式】 
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【药物名称】Didox, NSC-324360 【化学名称】3,4-Dihydroxybenzohydroxamic acid 【CA登记号】69839-83-4 【 分 子 式 】C7H7NO4 【 分 子 量 】169.13814 |
【开发单位】Molecules for Health (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, ONCOLYTIC DRUGS, Antimetabolites, Ribonucleoside-Diphosphate Reductase Inhibitors |
合成路线1
The esterification of 3,4-dihydroxybenzoic acid (I) with refluxing methanol - H2SO4 gives the corresponding methyl ester (II), which is then treated with hydroxylamine in water containing NaOH.
| 【1】 Van't Riet, B.; Elford, H.L.; Wampler, G.L. (Molecules for Health, Inc.); Hydroxy benzohydroxamic acids and benzamides. US 4263322 . |
| 【2】 Prous, J.; Castaner, J.; DIDOX. Drugs Fut 1990, 15, 1, 22. |
| 【3】 Van't Riet, B.; Wampler, G.L.; Elford, H.W.; Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: Inhibition of ribonucleotide reductase and antitumor activity. J Med Chem 1979, 22, 5, 589-92. |
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