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【结 构 式】 
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【药物名称】TK-117 【化学名称】3-(3',4'-Methylenedioxybenzoyl)-2'-deoxy-5-fluoro-uridine 【CA登记号】74234-11-0 【 分 子 式 】C17H15FN2O8 【 分 子 量 】394.3161 |
【开发单位】Toyama (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
The acylation of 3',5'-di-O-(chloroacetyl)-5-fluoro-2'-deoxyuridine (I) with 3,4-methylenedioxybenzoyl chloride (II) by means of triethylamine in dichloromethane gives 3',5'-di-O-(chloroacetyl)-3-(3,4-methylenedioxybenzoyl)-2'-deoxy-5-fluorouridine (III), which is then hydrolyzed with triethylamine in methanol-THF.
| 【1】 Terashima, N.; Kitayama, I.; Yamaguchi, T.; Hiraiwa, T.; Omori, M.; Senoura, M.; Yotsuji, M.; Kodama, T.; Kodama, Y.; Aoyama, H. (Toyama Chemical Co., Ltd.); 5-Fluoro-(beta-uridine or 2'-deoxy-beta-uridine) derivatives, a process for producing the same and a carcinostatic agent containing the same. DE 2923368 . |
| 【2】 Castaner, J.; Castaner, R.M.; Hoshi, A.; Serradell, M.N.; TK-117. Drugs Fut 1987, 12, 9, 865. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28820 | [(2R,3S,5R)-3-[(2-chloroacetyl)oxy]-5-[5-fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl 2-chloroacetate | C13H13Cl2FN2O7 | 详情 | 详情 | |
| (II) | 28821 | 1,3-benzodioxole-5-carbonyl chloride | 20850-43-5 | C8H5ClO3 | 详情 | 详情 |
| (III) | 28822 | (2R,3S,5R)-5-[3-(1,3-benzodioxol-5-ylcarbonyl)-5-fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-2-[[(2-chloroacetyl)oxy]methyl]tetrahydro-3-furanyl 2-chloroacetate | C21H17Cl2FN2O10 | 详情 | 详情 |
Extended Information