Ilepcimide, Antiepilepsirine, -Drug Synthesis Database

【结构式】

【药物名称】Ilepcimide, Antiepilepsirine

【化学名称】(E)-1-[3,4-(Methylenedioxy)cinnamoyl]piperidine
　　　　　　(E)-1-[3-(1,3-Benzodioxol-5-yl)-1-oxo-2-propenyl]piperidine

【CA登记号】82857-82-7, 23434-86-8 (undefined isomer)

【分子式】C₁₅H₁₇NO₃

【分子量】259.30764

【开发单位】Beijing Medical University (Originator)

【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS

合成路线1

3,4-Methylenedioxycinnamic acid (I) is transformed into the corresponding acid chloride (II) by treatment with oxalyl chloride in benzene. The acid chloride is then converted without purification into antiepilepsirine by treatment with piperidine in benzene.

参考文献中间体

【1】 Ruyun, J.; ANTIEPILEPSIRINE. Drugs Fut 1990, 15, 4, 331.
【2】 Pei, Y.; Li, J.; Cai, Z.; Zhang, B.; Ku, B.; Pharmacological study of tablettae antiepilepticae I. Its effect on the CNS. Nat Med J China 1978, 58, 4, 216-9.
【3】 Wang, S.; Li, R.; Liu, W.; et al.; Structure-anticonvulsant activity relationships of some cinnamamides of substituted aromatic ring. Acta Pharm Sin 1986, 21, 7, 542-5.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	10158	Piperidine	110-89-4	C₅H₁₁N	详情	详情
(I)	11634	(E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid; 3,4-(Methylenedioxy)cinnamic acid	2373-80-0	C₁₀H₈O₄	详情	详情
(II)	11635	(E)-3-(1,3-Benzodioxol-5-yl)-2-propenoyl chloride		C₁₀H₇ClO₃	详情	详情

Extended Information