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【结 构 式】 
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【药物名称】Actarit, MS-932, Mover, Orcl 【化学名称】2-(4-Acetamidophenyl)acetic acid 【CA登记号】18699-02-0 【 分 子 式 】C10H11NO3 【 分 子 量 】193.20407 |
【开发单位】Mitsubishi Chemical (Originator), Nippon Shinyaku (Licensee) 【药理作用】Antiarthritic Drugs, Rheumatoid Arthritis, Treatment of, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES |
合成路线1
The esterification of 4-aminophenylacetic acid (I) with ethanol - HCl in the usual way gives the ethyl ester (II), which is acylated with acetic anhydride in ethyl acetate yielding ethyl 4-acetaminophenylacetate (III). Finally, this compound is hydrolyzed with aqueous NaOH.
| 【1】 Sato, S.; Tsurufuji, M.; Enomoto, H.; Sugiyama, M.; Shibata, Y.; Morita, I.; Munakata, H.; Kobayashi, M.; Wagatsuma, K. (Mitsubishi Chem. Inds. Co.; Ltd.); Immunomodulating agents. DE 3317107; US 4720506 . |
| 【2】 Prous, J.; Castaner, J.; MS-932. Drugs Fut 1989, 14, 8, 759. |
Extended Information