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【结 构 式】 
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【药物名称】Dotarizine, FI-6026 【化学名称】1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2- yl)propyl]piperazine 【CA登记号】84625-59-2 【 分 子 式 】C29H34N2O2 【 分 子 量 】442.60653 |
【开发单位】Ferrer (Originator), Bertek (Licensee), Galephar PR (Licensee) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Antimigraine Drugs, Migraine, Prophylactic Treatment of, 5-HT2 Antagonists, Calcium Channel Blockers |
合成路线1
The title compound was synthesized by alkylation of 1-benzhydrylpiperazine (I) with 2-(3-chloropropyl)-2-phenyl-1,3-dioxolan (II) in the presence of NaHCO3 in refluxing EtOH.
| 【1】 Foguet, R.; Gubert, S.; Raga, M.M.; Ortiz, J.A.; Sacristan, A. (Ferrer Internacional SA); Piperazine derivs., a process for preparing them and pharmaceutical compsns.. EP 0097340 . |
Extended Information