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【结 构 式】 
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【药物名称】Lobenzarit sodium, CCA, Carfenil 【化学名称】4-Chloro-2,2'-iminidibenzoic acid disodium salt 【CA登记号】64808-48-6, 63329-53-3 (free acid) 【 分 子 式 】C14H8ClNNa2O4 【 分 子 量 】335.65676 |
【开发单位】Chugai (Originator) 【药理作用】Antiarthritic Drugs, IMMUNOMODULATING AGENTS, Immunomodulators, Rheumatoid Arthritis, Treatment of, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES |
合成路线1
By condensation of 2,4-dichlorobenzoic acid (I) with anthranilic acid (II) by means of K2CO3, powdered Cu and a small amount of I2 in refluxing isoamyl alcohol.
| 【1】 Tanemura, M.; et al.; Aminobenzoesaurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel. BE 0842832; DE 2526092; JP 52012141 . |
| 【2】 Tomcufcik, A.S.; Dusza, J.P.; Albright, J.D.; Beer, B. (Wyeth); N-Methyl-N-(-[3-[-2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl]phenyl)acetamide and compsns. and methods related thereto. US 6399621 . |
Extended Information