ICF-650, LS-93266, -Drug Synthesis Database

【结构式】

【药物名称】ICF-650, LS-93266

【化学名称】4-[2-(2-Phenylethyl)benzyl]morpholine hydrochloride

【CA登记号】119923-79-4

【分子式】C₁₉H₂₄ClNO

【分子量】317.86223

【开发单位】Università degli Studi di Bologna (Originator), Università degli Studi di Padova (Originator)

【药理作用】Non-Steroidal Antiinflammatory Drugs

合成路线1

4-[2-(2-Phenylethyl)benzyl]morpholine hydrochloride (ICF-650) has been obtained as follows: Methyl 2-(2-phenylethyl)benzoate (I) is reduced (LiAlH4) to the corresponding alcohol, converted (SOCl2) to (II) and then condensed with morpholine to give ICF-650.

参考文献中间体

【1】 Carrara, M.; Rampa, A.; ICF-650. Drugs Fut 1987, 12, 1, 22.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	10388	Morpholine	110-91-8	C₄H₉NO	详情	详情
(I)	22938	methyl 2-phenethylbenzoate		C₁₆H₁₆O₂	详情	详情
(II)	22939	1-(chloromethyl)-2-phenethylbenzene		C₁₅H₁₅Cl	详情	详情

Extended Information