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【结 构 式】 
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【药物名称】 【化学名称】2-(4-Isobutylphenyl)propionic acid 3-[5-oxido-4-(phenylsulfonyl)-1,2,5-oxadiazol-3-yloxy]propyl ester 【CA登记号】 【 分 子 式 】C24H28N2O7S 【 分 子 量 】488.56396 |
【开发单位】Ist. di Ricerche Farmacol. Mario Negri (Originator), Università degli Studi di Parma (Originator), Università degli Studi di Torino (Originator) 【药理作用】Antiarthritic Drugs, Antiplatelet Therapy, Chemical Delivery Systems, Coagulation Disorders Therapy, DRUG DELIVERY, Drug Delivery Systems, HEMATOLOGIC DRUGS, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Nitric Oxide Donors, Non-Steroidal Antiinflammatory Drugs |
合成路线1
The furazanyloxypropanol derivative (III) was obtained by condensation of 3,4-bis(benzenesulfonyl)furoxan (I) with 1,3-propanediol (II) in the presence of NaOH. Subsequent acylation of alcohol (III) with ibuprofen acid chloride (IV) provided the corresponding ibuprofen ester.
| 【1】 Lolli, M.L.; et al.; A new class of ibuprofen derivatives with reduced gastrotoxicity. J Med Chem 2001, 44, 21, 3463. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52494 | 3,4-bis(phenylsulfonyl)-1,2,5-oxadiazol-2-ium-2-olate | C14H10N2O6S2 | 详情 | 详情 | |
| (II) | 14685 | 1,3-propanediol; Trimethylene Glycol | 504-63-2 | C3H8O2 | 详情 | 详情 |
| (III) | 52495 | 4-[(3-hydroxypropyl)oxy]-3-(phenylsulfonyl)-1,2,5-oxadiazol-2-ium-2-olate | C11H12N2O6S | 详情 | 详情 | |
| (IV) | 22117 | 2-(4-isobutylphenyl)propanoyl chloride | C13H17ClO | 详情 | 详情 |