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【结 构 式】 
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【药物名称】 【化学名称】1,5-Bis[4,7-bis(7-chloroquinolin-4-yl)-1,4,7-triazanonan-1-yl]pentan-1,5-dione 【CA登记号】 【 分 子 式 】C53H50Cl4N10O2 【 分 子 量 】1000.86725 |
【开发单位】CNRS (Originator), Tibotec-Virco (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases |
合成路线1
Condensation of 1,4,7-triazacyclononane (I) with 4,7-dichloroquinoline (II) produced the disubstituted derivative (III). Then, coupling of glutaric acid (IV) with amine (III) using bromo-tris-pyrrolidinophosphonium hexafluorophosphate gave the corresponding diamide.
| 【1】 Girault, S.; Grellier, P.; Sergheraert, C.; Lemière, P.; Maes, L.; Davioud-Charvet, E.; Berceibar, A.; Mouray, E.; Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers. J Med Chem 2001, 44, 11, 1658. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 50898 | Octahydro-1H-1,4,7-triazonine; 1,4,7-Triazacyclononane; Triethylenetriamine | 4730-54-5 | C6H15N3 | 详情 | 详情 |
| (II) | 38277 | 4,7-dichloroquinoline | 86-98-6 | C9H5Cl2N | 详情 | 详情 |
| (III) | 50899 | 7-chloro-4-[4-(7-chloro-4-quinolinyl)-1,4,7-triazonan-1-yl]quinoline | C24H23Cl2N5 | 详情 | 详情 | |
| (IV) | 50900 | Pentanedioic Acid; 1,5-Pentanedioic acid; 1,3-Propanedicarboxylic acid; Glutaric acid | 110-94-1 | C5H8O4 | 详情 | 详情 |
Extended Information