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【结 构 式】 
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【药物名称】 【化学名称】(OC-6-22-DELTA)-Diaquabis(L-threoninato-kappaN,kappaO1)zinc 【CA登记号】65312-22-3 【 分 子 式 】C8H20N2O8Zn 【 分 子 量 】337.6272 |
【开发单位】Japan Science and Technology (Originator), Kyoto Pharmaceutical University (Originator), Osaka City University (Originator), Teikyo University (Originator) 【药理作用】Antidiabetic Drugs, ENDOCRINE DRUGS, Type 2 Diabetes Mellitus, Agents for, Glucose Lowering Agents, Metal Complexes |
合成路线1
The title zinc complex is prepared by adding ZnSO4 to an aqueous solution of the lithium salt of L-threonine.
| 【1】 Sakurai, H.; Yanagihara, N.; Suzuki, Y.; Ueda, E.; Kojima, Y.; Yoshikawa, Y.; New insulinomimetic zinc(II) complexes of alpha-amino acids and their derivatives with Zn(N2O2) coordination mode. Chem Pharm Bull 2001, 49, 5, 652. |
| 【2】 Sakurai, H.; Kojima, Y. (Japan Science and Technology Corp.); Blood glucose lowering agents containing zinc(II) organic complex. EP 1256342; JP 2001220348; WO 0139769 . |
Extended Information