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【结 构 式】 
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【药物名称】NIBA, AntiPARP-2, INO2BA 【化学名称】4-Iodo-3-nitrobenzamide 【CA登记号】160003-66-7 【 分 子 式 】C7H5IN2O3 【 分 子 量 】292.0339 |
【开发单位】Octamer (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, ONCOLYTIC DRUGS, NAD+ ADP-Ribosyltransferase (poly(ADP-ribose)polymerase; PARP) Inhibitors |
合成路线1
The title benzamide derivative was prepared from 4-iodo-3-nitrobenzoic acid (I), by activation as the corresponding acid chloride (II) with SOCl2 in DMF, followed by quenching with concentrated ammonium hydroxide.
| 【1】 Kun, E.; Mendeleyev, J.; Kirsten, E. (Octamer, Inc.); Novel aromatic and nitroso cpds. and their metabolites useful as anti-viral and anti-tumor agents. WO 9426730 . |
Extended Information