|
【结 构 式】 
|
【药物名称】 【化学名称】4-Amino-5-chloro-2-methoxy-N-[1-[2-(methylsulfonamido)ethyl]piperidin-4-ylmethyl]benzamide oxalate 【CA登记号】 【 分 子 式 】C19H29ClN4O8S 【 分 子 量 】508.98198 |
【开发单位】Mitsubishi Pharma (Originator) 【药理作用】PHARMACOLOGICAL TOOLS, 5-HT4 Agonists |
合成路线1
4-Amino-5-chloro-2-methoxybenzoic acid (I) was coupled to 4-(aminomethyl)-1-[2-(methylsulfonylamino)ethyl]piperidine (II) employing 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride and 1-hydroxybenzotriazole. The resulting compound was then treated with oxalic acid to provide the corresponding oxalate salt.
| 【1】 Kawakita, T.; Haga, K.; Itoh, K.; Ikebe, T.; kanzaki, K.; Sato, N.; Tomozane, H.; Sonda, S.; Kuroita, T.; Synthesis and pharmacological evaluation of carboxamide derivatives as selective serotoninergic 5-HT4 receptor agonists. Eur J Med Chem 1999, 34, 11, 977. |
Extended Information