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【结 构 式】 
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【药物名称】GR-215864X, GW-215864X 【化学名称】6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-(propionyloxy)androsta-1,4-diene-17beta-carbothioic acid S-(2-oxotetrahydrofuran-3-yl)ester 【CA登记号】192056-79-4 ((R)-isomer), 192056-77-2 ((S)-isomer) 【 分 子 式 】C28H34F2O7S 【 分 子 量 】552.63978 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Drugs for Allergic Rhinitis, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Corticosteroids |
合成路线1
The title compound was prepared by condensation of the carbothioic acid (I) with alpha-bromo-gamma-butyrolactone (II) in the presence of K2CO3 in DMF.
| 【1】 Biggadike, K.; Procopiou, P.A. (Glaxo Wellcome plc); Lactone derivs. of 17beta-carboxy, carbothio and amide androstane derivs.. JP 1999501675; US 6197761; WO 9724365 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14478 | (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid | C24H30F2O5S | 详情 | 详情 | |
| (II) | 22822 | 3-bromodihydro-2(3H)-furanone | 5061-21-2 | C4H5BrO2 | 详情 | 详情 |
Extended Information