【结 构 式】 |
【药物名称】MCI-154 【化学名称】6-[4-(4-Pyridylamino)phenyl]-2,3,4,5-tetrahydropyridazin-3-one hydrochloride 【CA登记号】98326-33-1 【 分 子 式 】C15H15ClN4O 【 分 子 量 】302.766 |
【开发单位】Mitsubishi Pharma (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy, Calcium Sensitizers, Phosphodiesterase III Inhibitors |
合成路线1
By condensation of 6-(4aminophenyl)2,3,4,5-tetrahydropyridazin-3-one (I) with 4-bromopyridine (II) in hot DMF, followed by extraction of the free base with Na2CO3 and treatment with ethanolic HCl.
【1】 Kobayashi, M.; Narimatsu, A.; Furuya, R.; Shimooda, I.; Kitada, Y.; Okushima, H. (Mitsubishi Chemical Corp.); 6-(p-Heterocyclylaminophenyl)pyridazin-3-one derivs.. EP 0145019; JP 1985126282; JP 1985197672; US 4661484; US 4971968 . |
【2】 Castaner, R.M.; Serradell, M.N.; Castaner, J.; MCI-154. Drugs Fut 1987, 12, 9, 856. |
Extended Information