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【结 构 式】 
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【药物名称】Inaperisone hydrochloride, YM-170, HY-770U, HSR-770, HN-770, Inapen, Riran 【化学名称】(±)-4'-Ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride 【CA登记号】90878-85-6, 99323-21-4 (free base) 【 分 子 式 】C16H24ClNO 【 分 子 量 】281.82878 |
【开发单位】Abbott (Originator), Yamanouchi (Licensee) 【药理作用】Antispastic Drugs and Drugs for Muscle Spasms, Muscle Spasms, Drugs for, NEUROLOGIC DRUGS, RENAL-UROLOGIC DRUGS, Smooth Muscle Relaxants, Urinary Incontinence Therapy |
合成路线1
By condensation of pyrrolidine (I) with paraformaldehyde (II) and 4-ethylpropiophenone (III) by means of dry HCl in refluxing ethyl acetate.
| 【1】 Susumu, O.; Masaru, S.; Tomio, Y.; Yutaka, N.; Masatoshi, H. (Nippon Chemiphar Co., Ltd.); Benzimidazole derivs. and antiulcer agents contain. AU 8546409; BE 0903128; CH 665417; DE 3531487; ES 8703142; FR 2569691; GB 2163747; JP 1986060660; JP 1986221175; JP 1986221176; JP 1991223260; JP 1991223261; JP 1991223262; JP 1991227927 . |
| 【2】 Itho, Y.; Kato, H.; Koshinaka, E.; Nishino, H.; Ogawa, N. (Hokuriku Seiyaku Co., Ltd.); Derivs. of 3-pyrrolidinopropiophenone and a proces. FR 2559771 . |
| 【3】 Itho, Y.; Kato, H.; Koshinaka, E.; Nishino, H.; Ogawa, N. (Hokuriku Seiyaku Co., Ltd.); Derivs. of 3-pyrrolidinopropiophenone and a proces. EP 0150235 . |
| 【4】 Prous, J.; Castaner, J.; HSR-770. Drugs Fut 1988, 13, 4, 310. |
Extended Information