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【结 构 式】 
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【药物名称】PM-170 【化学名称】3-Hydroxymethyl-N-methylpiperidine (4-chlorophenoxy)acetate hydrochloride 【CA登记号】80842-08-6, 80842-07-5 (free base) 【 分 子 式 】C15H21Cl2NO3 【 分 子 量 】334.24552 |
【开发单位】ANVAR (Originator) 【药理作用】Antiobesity Drugs, Lipoprotein Disorders, Treatment of , METABOLIC DRUGS, Treatment of Nutritional Disorders |
合成路线1
PM-170 is synthesized by esterification of 4-chlorophenoxyacetic acid chloride (I) and 3-hydroxymethyl-N-methylpiperidine (II) in dry benzene. PM-170 is recrystallized from ethanol.
| 【1】 Massicot, F.; et al.; Antiobesity activity of a new cyclic amino aryloxyacetate in obese rats and mice. Eur J Med Chem - Chim Ther 1985, 20, 559. |
| 【2】 Godfroid, J.J.; Massicot, F.; PM-170. Drugs Fut 1986, 11, 10, 848. |
Extended Information