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【结 构 式】 
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【药物名称】Apyramide, R025 【化学名称】1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(acetylamino)phenyl ester 【CA登记号】68483-33-0 【 分 子 式 】C27H23ClN2O5 【 分 子 量 】490.94776 |
【开发单位】Marcel Richard (Originator) 【药理作用】Non-Steroidal Antiinflammatory Drugs |
合成路线1
The esterification of indomethacin (I) with paracetamol (II) in the presence of DCC is performed in pyridine to afford apyramide, which is recrystallized in isopropanol.
| 【1】 Serrano, J.J.; Richard, M.; Sauvaire, D.; Michel, A.; Apyramide. Drugs Fut 1987, 12, 3, 203. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22930 | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid | C19H16ClNO4 | 详情 | 详情 | |
| (II) | 21611 | 4'-Hydroxyacetanilide;4-Acetamidophenol;N-Acetyl-4-aminophenol;Paracetamol;Acetaminophen;p-Hydroxyacetanilide; Paracetamol; N-(4-hydroxyphenyl)acetamide | 103-90-2 | C8H9NO2 | 详情 | 详情 |
Extended Information