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【结 构 式】 
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【药物名称】Hexamethylenebisacetamide, HMBA, NSC-95580, Hexabid 【化学名称】N,N'-Hexamethylenebisacetamide 【CA登记号】3073-59-4 【 分 子 式 】C10H20N2O2 【 分 子 量 】200.2831 |
【开发单位】National Cancer Institute (Originator), Memorial Sloan-Kettering Cancer Center (Licensee) 【药理作用】Oncolytic Drugs |
合成路线1
Hexamethylenebisacetamide is prepared by reacting 1,6-hexanediamine (I) with two moles of acetic acid.
| 【1】 Friend, C.; et al.; Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: Stimulation of erythroid differentiation by dimethyl sulfoxide. Proc Natl Acad Sci USA 1976, 73, 3, 862. |
| 【2】 Grimmelikhuysen, J.; Schroeder, A. (Unilever NV); Preparation of polyacetylalkylenediamines. BE 769655; DE 2133458; FR 2100320; GB 1335204 . |
| 【3】 Eastland, G.; HMBA. Drugs Fut 1986, 11, 11, 933. |
Extended Information