Verapamil, Calan, Securon, Cordilox, Verelan PM, Chronovera, Covera-HS(controlled onset, extended release system), Isoptin(HCl), -Drug Synthesis Database

【结构式】

【药物名称】Verapamil, Calan, Securon, Cordilox, Verelan PM, Chronovera, Covera-HS(controlled onset, extended release system), Isoptin(HCl)

【化学名称】5-[N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile

【CA登记号】52-53-9, 152-11-4 (HCl)

【分子式】C₂₇H₃₈N₂O₄

【分子量】454.61491

【开发单位】Abbott (Originator), Pfizer (Licensee)

【药理作用】Acute Myocardial Infarction, Treatment of, Angina pectoris, Treatment of, Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Calcium Channel Blockers, Dopamine D2 Antagonists

合成路线1

The condensation of 2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) by means of sodium amide in refluxing toluene gives the target aminonitrile.

参考文献中间体

【1】 Dengel, F. (Knoll AG); Basically substd. phenyl acetonitrile cpds.. US 3261859 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30391	2-(3,4-dimethoxyphenyl)-3-methylbutanenitrile; alpha-Isopropylveratryl cyanide	20850-49-1	C₁₃H₁₇NO₂	详情	详情
(II)	29986	3-chloro-N-(3,4-dimethoxyphenethyl)-N-methyl-1-propanamine; N-(3-chloropropyl)-N-(3,4-dimethoxyphenethyl)-N-methylamine		C₁₄H₂₂ClNO₂	详情	详情

Extended Information