Cimetropium bromide, DA-3177, Alginor, -Drug Synthesis Database

【结构式】

【药物名称】Cimetropium bromide, DA-3177, Alginor

【化学名称】[7(S)-(1alpha,2beta,4beta,5alpha,7beta)]-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane bromide

【CA登记号】51598-60-8

【分子式】C₂₁H₂₈BrNO₄

【分子量】438.36561

【开发单位】Boehringer Ingelheim (Originator), De Angeli (Originator), Nippon Boehringer Ingelheim (Originator)

【药理作用】Antispasmodics, GASTROINTESTINAL DRUGS, Irritable Bowel Syndrome, Agents for

合成路线1

By quaternization of scopolamine base (I) with cyclopropylmethyl bromide (II) in refluxing acetonitrile.

参考文献中间体

【1】 Casadio, S.; Donetti, A.; Certain N-substituted Scopolammonium compounds. DE 2316728; FR 2187333; GB 1413484; JP 49014615; US 3853886 .
【2】 de Angelis, L.; Castaner, J.; DA-3177. Drugs Fut 1978, 3, 7, 509.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33527	(1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2R)-3-hydroxy-2-phenylpropanoate		C₁₇H₂₁NO₄	详情	详情
(II)	22277	Cyclopropyl bromide; 1-(Bromomethyl)cyclopropane	7051-34-5	C₄H₇Br	详情	详情

Extended Information