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【结 构 式】 
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【药物名称】Nimodipine, Bay-e-9736, Periplum, Admon, Nimotop 【化学名称】1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) diester 【CA登记号】66085-59-4 【 分 子 式 】C21H26N2O7 【 分 子 量 】418.45057 |
【开发单位】Bayer (Originator), Esteve (Licensee), Italfarmaco (Licensee) 【药理作用】Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Calcium Channel Blockers |
合成路线1
By cyclocondensation of a mixture of isopropyl(m-nitrobenzylidene)acetylacetate (II), 2-methoxyethyl acetylacetate (I) and NH3 in refluxing ethanol.
| 【1】 Meyer, H.; et al.; Unsymmetrical esters of 1,4-dihydropyridine-3,5-dicarboxylic acid. BE 0781878; DE 2117571; FR 2132830; GB 1358951; US 3799934 . |
| 【2】 Castaner, J.; Serradell, M.N.; Mealy, N.E.; Blancafort, P.; Leeson, P.A.; Nimodipine. Drugs Fut 1981, 6, 2, 98. |
Extended Information