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【结 构 式】 
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【药物名称】CPDS 【化学名称】6,6'-Dithiodinicotinic acid 【CA登记号】15658-35-2 【 分 子 式 】C12H8N2O4S2 【 分 子 量 】308.33656 |
【开发单位】Università degli Studi di Padova (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
6-Chloronicotinic acid (I) is reacted with thiourea (II) to give 6-mercaptonicotinic acid (III) This is oxidized to the disulfide with iodine or hydrogen peroxide.
| 【1】 Grassetti, D.R.; et al.; The effects of some disulfides and thiols on the carbohydrate metabolism of Ehrlich ascites tumor. J Med Chem 1967, 10, 6, 1170. |
| 【2】 Grassetti, D.R.; CPDS. Drugs Fut 1986, 11, 7, 559. |
Extended Information