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【结 构 式】 
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【药物名称】Trandolapril, RU-44570, Preran, Mavik, Tarka(comb. with verapamil), Udrik, Gopten, Odrik 【化学名称】(2S,3aR,7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]hexahydro-2-indolinecarboxylic acid 1-ethyl ester 【CA登记号】87679-37-6 【 分 子 式 】C24H34N2O5 【 分 子 量 】430.54898 |
【开发单位】Aventis Pharma (Originator), Nippon Roussel (Originator), Abbott (Licensee), Chugai (Licensee) 【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy, Hypertension, Treatment of, Angiotensin-I Converting Enzyme (ACE) Inhibitors |
合成路线1
The esterification of (3aR,7aS)-octahydroindole-2(S)-carboxylic acid (I) with benzyl alcohol (II) by means of SOCl2 gives the corresponding benzyl ester (III), which is condensed with N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine (IV) by means of 1-hydroxybenzotriazole, N-ethylmorpholine and dicyclohexylcarbodiimide (DCC) in DMF giving the benzyl ester (V) of the desired product. Finally, this compound is debenzylated by hydrogenation with H2 over Pd/C in ethanol.
| 【1】 Ubach, H.; Henning, R.; Teetz, V.; Geiger, R.; Becker, R.; Gaul, H. (Aventis SA); Novel bicyclic amino acid derivs., process for their preparation and their use , as well as bicyclic amino acids as intermediates and process for their preparation. DE 3151690; EP 0084164; EP 0170775; JP 1989301659; JP 1989301695 . |
| 【2】 Prous, J.; Castaner, J.; TRANDOLAPRIL < Rec INN >. Drugs Fut 1989, 14, 8, 778. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19512 | (2S,3aR,7aS)octahydro-1H-indole-2-carboxylic acid | 145438-94-4 | C9H15NO2 | 详情 | 详情 |
| (II) | 18710 | Benzyl alcohol; Phenylmethanol | 100-51-6 | C7H8O | 详情 | 详情 |
| (III) | 19514 | benzyl (2S,3aR,7aS)octahydro-1H-indole-2-carboxylate | 144540-71-6 | C16H21NO2 | 详情 | 详情 |
| (IV) | 11360 | (2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionic acid; (S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)-(S)-alanine | 82717-96-2 | C15H21NO4 | 详情 | 详情 |
| (V) | 19516 | benzyl (2S,3aR,7aS)-1-((2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl)octahydro-1H-indole-2-carboxylate | 98677-37-3 | C31H40N2O5 | 详情 | 详情 |