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【结 构 式】 
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【药物名称】Ibudilast, KC-404, Eyevinal(Ophthalmic), Ketas 【化学名称】3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine 【CA登记号】50847-11-5 【 分 子 式 】C14H18N2O 【 分 子 量 】230.31236 |
【开发单位】Kyorin (Originator), Banyu (Licensee) 【药理作用】Antiallergic Ophthalmic Agents, Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Immunologic Neuromuscular Disorders, Treatment of, Multiple Sclerosis, Agents for, NEUROLOGIC DRUGS, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, RESPIRATORY DRUGS, Leukotriene CysLT1 (LTD4) Antagonists, Mediator Release Inhibitors |
合成路线1
By condensation of 1-amino-2-methylpyridinium iodide (I) with isobutyric anhydride (II) by means of K2CO3 at reflux temperature.
| 【1】 Irikura, T.; et al. (Kyorin Pharmaceutical Co., Ltd.); 2-Alkyl-3-acylpyrazolo[1,5-a]pyridines. DE 2315801; FR 2182914; JP 7714799 . |
| 【2】 Procopiou, P.A. (GlaxoSmithKline plc); A novel process for preparing salmeterol. WO 0196278 . |