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【结 构 式】 
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【药物名称】Tesmilifene hydrochloride, BMY-33419, BMS-217380, DPPE, N, N-DPPE 【化学名称】2-(4-Benzylphenoxy)-N,N-diethylethylamine hydrochloride 【CA登记号】92981-78-7, 98774-23-3 (free base) 【 分 子 式 】C19H26ClNO 【 分 子 量 】319.87817 |
【开发单位】YM BioSciences (Proprietary), University of Manitoba (Originator), Bristol-Myers Squibb (Not Determined) 【药理作用】Antineoplastic Enhancing Agents, Modulators of the Therapeutic Activity of Antineoplastic Agents, ONCOLYTIC DRUGS, Antiestrogens, Histamine Receptor Antagonists |
合成路线1
The target product can be prepared by reacting para-benzylphenol (I) with 2-diethylaminoethylchloride hydrochloride (II) either by means of NaOH in H2O or with K2CO3 in DMF/acetone (at 60 C in both cases), followed by treatment with HCl to obtain the corresponding hydrochloride salt.
| 【1】 Delarue, F.; Poirot, M.; Klaebe, A.; De Medina, P.; Faye, J.-C.; Perie, J.-J.; Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS). Bioorg Med Chem 2000, 8, 8, 2007. |
| 【2】 Hermonat, M.W.; Brandes, L.J. (University of Manitoba); Novel cytotoxic aminoalkyl phenol ethers. EP 0153160; JP 1985190742; US 4803227 . |