Erythromycin acistrate, Erasis, -Drug Synthesis Database

【结构式】

【药物名称】Erythromycin acistrate, Erasis

【化学名称】2'-Acetylerythromycin stearate
　　　　　　13-Ethyl-2,4,6,8,10,12-hexamethyl-6,11,12-trihydroxy-9-oxo-3-(3-hydroxy-4-methoxy-2,4-dimethyltetrahydropyran-6-yloxy)-4-(3-acetoxy-4-dimethylamino-6-methyltetrahydropyran-2-yloxy)tridecanolide stearate

【CA登记号】96128-89-1

【分子式】C₅₇H₁₀₅NO₁₆

【分子量】1060.4695

【开发单位】Orion Corp. (Originator)

【药理作用】Macrolides

合成路线1

By acetylation of erythromycin A (I) with acetyl chloride and NaHCO3 in ethyl acetate followed by reaction with stearic acid.

参考文献中间体

【1】 Honkanen, E.J.; Kairisalo, P.J.; Marttila, E.V.; Marvola, M.L.A.; Pippuri, A.K.; Uotila, J.A. (Orion Corporation); Acetyl erythromycin stearate, and compsns. contain. CH 666275; DE 3500179; FR 2557878; GB 2152502; JP 1985158197; US 4599326 .
【2】 Castaner, J.; Prous, J.; Erythromycin acistrate. Drugs Fut 1988, 13, 10, 910.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33087	(3R,4R,5R,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-2,10-oxacyclotetradecanedione; Erythromycin A	114-07-8	C₃₇H₆₇NO₁₃	详情	详情

Extended Information