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【结 构 式】 
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【药物名称】Brequinar sodium, NSC-368390, DuP-785 【化学名称】2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid sodium salt 【CA登记号】96201-88-6, 96187-53-0 (free acid) 【 分 子 式 】C23H14F2NNaO2 【 分 子 量 】397.36013 |
【开发单位】Bristol-Myers Squibb (Originator) 【药理作用】IMMUNOMODULATING AGENTS, Immunosuppressants, Oncolytic Drugs, Antimetabolites |
合成路线1
By cyclization of 5-fluoroisatin (I) with 4-(2-fluorophenyl)- propiophenone (II) by means of NaOH in refluxing ethanol - water.
| 【1】 Hesson, D.P. (DuPont Pharmaceuticals Co.); Phenylquinolinecarboxylic acids and derivatives as antitumor agents. AU 8430852; EP 0133244; JP 8542367; US 4680299 . |
| 【2】 Eastland, G. Jr.; Prous, J.; Castaner, J.; BREQUINAR SODIUM < Prop INNM >. Drugs Fut 1988, 13, 1, 13. |
Extended Information