EMD-30533, -Drug Synthesis Database

【结构式】

【药物名称】EMD-30533

【化学名称】2-(4-Hydroxy-4-phenylpiperidin-1-ylmethyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-one hydrochloride

【CA登记号】63579-73-7

【分子式】C₂₄H₃₀ClNO₄

【分子量】431.964

【开发单位】Merck KGaA (Originator)

【药理作用】Antipsychotic Drugs, PSYCHOPHARMACOLOGIC DRUGS

合成路线1

By condensation of 1-tetralone (I) with formaldehyde (II) and 4-phenyl piperidin-4-ol (III) in refluxing ethanol.

【1】 Muller-Calgan, H.; Jonas, R.; Uhl, J.; Irmscher, K. (Merck Patent GmbH); Tetralone and indanone derivs.. DE 2507782; NL 7601762 .
【2】 Serradell, M.N.; Castaner, J.; EMD-30533. Drugs Fut 1986, 11, 2, 101.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	16964	6,7-dimethoxy-1-tetralone; 6,7-dimethoxy-3,4-dihydro-1(2H)-naphthalenone	13575-75-2	C₁₂H₁₄O₃	详情	详情
(III)	28021	4-phenyl-4-piperidinol; 4-Hydroxy-4-phenylpiperidine; 4-(4-Phenyl)-4-hydroxypiperidine	40807-61-2	C₁₁H₁₅NO	详情	详情

Extended Information