Isradipine, PN-200110, Lomir, Icaz, DynaCirc, Prescal, -Drug Synthesis Database

【结构式】

【药物名称】Isradipine, PN-200110, Lomir, Icaz, DynaCirc, Prescal

【化学名称】Isopropyl (±)-4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate
　　　　　　(±)-4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester
　　　　　　(±)-4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl 5-methyl diester

【CA登记号】75695-93-1

【分子式】C₁₉H₂₁N₃O₅

【分子量】371.39632

【开发单位】Novartis (Originator), Sankyo (Marketer), Reliant Pharmaceuticals (Licensee)

【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Calcium Channel Blockers

合成路线1

By cyclization of 2,1,3-benzoxadiazole-4-carbaldehyde (I) with isopropyl acetoacetate (II) and methyl 3-aminocrotonate (III) in refluxing ethanol.

参考文献中间体

【1】 Neumann, P. (Novartis AG); Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compsns. containing them. US 4466972 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	35958	2,1,3-benzoxadiazole-4-carbaldehyde		C₇H₄N₂O₂	详情	详情
(II)	13332	isopropyl 3-oxobutanoate; Isopropyl acetoacetate	542-08-5	C₇H₁₂O₃	详情	详情
(III)	11372	Methyl (E)-3-amino-2-butenoate; Methyl 3-aminocrotonate		C₅H₉NO₂	详情	详情

Extended Information