Nefiracetam, DM-9384, DZL-221, Translon, -Drug Synthesis Database

【结构式】

【药物名称】Nefiracetam, DM-9384, DZL-221, Translon

【化学名称】N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide
　　　　　　2-Oxo-1-pyrrolidinylacetic acid 2,6-dimethylanilide
　　　　　　2-Oxo-1-pyrrolidineaceto-2',6'-xylidide

【CA登记号】77191-36-7

【分子式】C₁₄H₁₈N₂O₂

【分子量】246.31176

【开发单位】Daiichi Pharmaceutical (Originator)

【药理作用】Alzheimer's Dementia, Treatment of , Cerebrovascular Diseases, Treatment of, Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of

合成路线1

By condensation of 2-(2-oxopyrrolidino)acetic acid (I) with 2,6-dimethylaniline (II) by means of dicyclohexylcarbodiimide (DCC) in refluxing chloroform.

参考文献中间体

【1】 Betzing, H.; Biedermann, J.; Materne, C.; Neuser, V. (A. Nattermann & Cie. GmbH); Pyrrolidin-2-on-1-ylacetic acid 2,6-dimethylanilide, process of preparation and pharmaceutical compsns. containing them. DE 2924011 .
【2】 Prous, J.; Castaner, J.; DM-9384. Drugs Fut 1989, 14, 1, 17.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	19556	2-(2-oxo-1-pyrrolidinyl)acetic acid		C₆H₉NO₃	详情	详情
(II)	17527	2,6-Xylidine; 2,6-Dimethylaniline; 2,6-Dimethylphenylamine	87-62-7	C₈H₁₁N	详情	详情

Extended Information