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【结 构 式】 
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【药物名称】BIOLF-70 【化学名称】9-[2-(Benzyloxy)-1-(benzyloxymethyl)ethoxymethyl]-6-chloro-9H-purin-2-amine 【CA登记号】84222-47-9 【 分 子 式 】C23H24ClN5O3 【 分 子 量 】453.93243 |
【开发单位】ENS Biologicals (Originator), McGill University (Originator), Roche Bioscience (Licensee) 【药理作用】ANTIINFECTIVE THERAPY, Antiviral Drugs, IMMUNOMODULATING AGENTS, Immunomodulators |
合成路线1
By the condensation of 2-amino-6-chloropurine (I) (which has been silylated with 1,1,1,3,3,3-hexamethyldisilazane) with (1,3-dibenzyloxy-2-propoxy)methyl chloride (II) by means of mercuric cyanide in benzene at reflux. BIOLF-7O is purified by chromatography over silica gel.
| 【1】 Smith, K.O.; Kennell, W.L.; Galloway, K.S.; Cheriyan, U.O.; Ogilvie, K.K.; Radatus, B.K.; Biologically active acylnucleoside analogues. II. The synthesis of 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine (BIOLF-62). Can J Chem 1982, 60, 3005. |
| 【2】 Ogilvie, K.K.; Gauntt, C.J.; BIOLF-70. Drugs Fut 1986, 11, 10, 826. |
Extended Information