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【结 构 式】 
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【药物名称】SM-3163 【化学名称】3-[(1,5-Diphenylpentyl)oxy]-N,N-dimethyl-1-propanamine citrate 【CA登记号】77334-62-4 (ethanedioate (1:1)) 【 分 子 式 】C28H39NO8 【 分 子 量 】517.62493 |
【开发单位】Sumitomo Pharmaceuticals (Originator) 【药理作用】Cardiovascular Diseases (Not Specified), CARDIOVASCULAR DRUGS, Cognition Disorders, Treatment of, NEUROLOGIC DRUGS |
合成路线1
By condensation of 1,5-diphenyl-1-pentanol (I) with 3-(dimethylamino)propyl chloride (II) by means of NaH in refluxing toluene, followed by a treatment with citric acid.
| 【1】 Ono, K.; Kawakami, H.; Katsube, J. (Sumitomo Pharmaceuticals Co., Ltd.); Diphenylalkanoether and diphenylalkanone oximeether derivatives. EP 0017217; US 4388469; US 4426394; US 4482573; US 4620036 . |
| 【2】 Castaner, J.; Prous, J.; SM-3163. Drugs Fut 1986, 11, 12, 1046. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24580 | 1,5-diphenyl-1-pentanol | C17H20O | 详情 | 详情 | |
| (II) | 24581 | 3-(Dimethylamino)propyl chloride; 3-Chloro-N,N-dimethyl-1-propanamine | 5407-04-5 | C5H12ClN | 详情 | 详情 |
| (III) | 24582 | 3-[(1,5-diphenylpentyl)oxy]-N,N-dimethyl-1-propanamine | C22H31NO | 详情 | 详情 | |
| (IV) | 13856 | 2-Hydroxy-1,2,3-propanetricarboxylic acid; Citric acid | 77-92-9 | C6H8O7 | 详情 | 详情 |
Extended Information