|
【结 构 式】 
|
【药物名称】XC-386 【化学名称】3,4-Dimethylpyrano[2,3-c]pyrazol-6-one 【CA登记号】5203-98-5 【 分 子 式 】C8H8N2O2 【 分 子 量 】164.16516 |
【开发单位】China Medical College (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Non-Opioid Analgesics, Non-Steroidal Antiinflammatory Drugs |
合成路线1
Hydrazine hydrate (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.
| 【1】 J Taiwan Pharm Assoc 1979, 31, 47-55. |
| 【2】 Kuo, S.C.; et al.; Studies on heterocyclic compounds. 6. Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives. J Med Chem 1984, 27, 4, 539. |
| 【3】 Teng, C.M.; Kuo, S.C.; Wang, J.P.; XC-386. Drugs Fut 1985, 10, 9, 761. |
合成路线2
Suspension of 3-methyl-2-pyrazolin-5-one (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.
| 【1】 J Taiwan Pharm Assoc 1979, 31, 47-55. |
| 【2】 Kuo, S.C.; et al.; Studies on heterocyclic compounds. 6. Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives. J Med Chem 1984, 27, 4, 539. |
| 【3】 Teng, C.M.; Kuo, S.C.; Wang, J.P.; XC-386. Drugs Fut 1985, 10, 9, 761. |