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【结 构 式】 
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【药物名称】Propafenone hydrochloride, Pronon, Rytmonorm, Rhythmol 【化学名称】1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl-3-phenyl-1-propanone hydrochloride 【CA登记号】34183-22-7, 54063-53-5 (free base) 【 分 子 式 】C21H28ClNO3 【 分 子 量 】377.91521 |
【开发单位】Abbott (Originator), Yamanouchi (Not Determined) 【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS |
合成路线1
The condensation of beta-phenyl-2-hydroxypropiophenone sodium salt (I) with 1-chloro-2,3-epoxypropane (A) at 100 C yields beta-phenyl-2-(2',3'-epoxypropoxy)propiophenone (II). which is then treated with n-propylamine (B) also at 100 C.
| 【1】 Beck, O.A.; et al.; Einfluß des antiarrhythmikus propafenon auf die intrakardiale erregungsleitung. Z Kardiol 1975, 64, 731-740. |
| 【2】 Sauchse, R.; 2-Hydroxy-3-phenylpropiophenone derivatives. AT 308076B; BE 0785318; DE 2001431; FR 2144601; GB 1307455; NL 7208214 . |
| 【3】 Prigge, E.; Hapke, H.J.; Zur Pharmakologie von 2'-[2-Hydroxy-3-(propylamino).propoxy]-3-phenylpropiophenon (Propafenon, SA79)-hydrochlorid. Arzneim-Forsch Drug Res 1976, 36, 10, 1849-57. |
| 【4】 Castaner, J.; Bahring-Kuhmley, S.R.; Propafenone. Drugs Fut 1977, 2, 5, 325. |
Extended Information