【结 构 式】 |
【药物名称】Lofepramine hydrochloride, Gamanil, Gamonil 【化学名称】1-(4-Chlorophenyl)-2-[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylmethylamino]ethanone monohydrochloride 【CA登记号】26786-32-3, 23047-25-8 (free base) 【 分 子 式 】C26H28Cl2N2O 【 分 子 量 】455.43186 |
【开发单位】Merck & Co. (Originator), Merck KGaA (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS |
合成路线1
By condensation of N-methyl-3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylamine (desipramine) (I) with 4-chlorophenacyl chloride (II) by means of NaHCO3 in benzene-water.
【1】 Eriksoo, E.; Rohte, O.; Chemistry and pharmacology of a new potential antidepressant. Arzneim-Forsch Drug Res 1970, 20, 10, 1561. |
【2】 Castaner, J.; Arrigoni-Martelli, E.; Lofepramine. Drugs Fut 1976, 1, 3, 129. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 34005 | N-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N-methylamine; 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1-propanamine | C18H22N2 | 详情 | 详情 | |
(II) | 16720 | 2-bromo-1-(4-chlorophenyl)-1-ethanone; 2-Bromo-4'-chloroacetophenone | 536-38-9 | C8H6BrClO | 详情 | 详情 |
Extended Information