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【结 构 式】 
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【药物名称】Meclofenamate sodium, CI-853(free acid), Meclodol, Meclomen 【化学名称】2-(2,6-Dichloro-3-methylphenylamino)benzoic acid sodium salt hydrate 【CA登记号】6385-02-0, 644-62-2 (free acid) 【 分 子 式 】C14H12Cl2NNaO3 【 分 子 量 】336.15244 |
【开发单位】Pfizer (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiarthritic Drugs, Non-Opioid Analgesics, Rheumatoid Arthritis, Treatment of, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Non-Steroidal Antiinflammatory Drugs |
合成路线1
By condensation of o-bromobenzoic acid (I) with 2,6-dichloro-3-methylaniline (II) by means of CuBr2 in diethylene glycol dimethyl ether containing N-ethylmorpholine and heated at 145-55 C.
| 【1】 Scherrer, R.A.; Short, F.W.; Anthranilic acids and derivatives. US 3313848 . |
| 【2】 Arrigoni-Martelli, E.; Castaner, J.; Meclofenamic acid. Drugs Fut 1978, 3, 4, 307. |
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