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【结 构 式】 
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【药物名称】Flumecinol, RGH-3332, Zixoryn 【化学名称】alpha-Ethyl-3-(trifluoromethyl)benzhydrol 【CA登记号】56430-99-0 【 分 子 式 】C16H15F3O 【 分 子 量 】280.29255 |
【开发单位】Gedeon Richter (Originator), Farmacon (Licensee) 【药理作用】GASTROINTESTINAL DRUGS, Hepatoprotectants, Liver and Biliary Tract Disorders, Treatment of |
合成路线1
By a Grignard reaction between 3-trifluoromethylphenylmagnesium bromide (I) and propiophenone (II) in ethyl ether.
| 【1】 Edit, T.; et al. (Gedeon Richter Ltd.); alpha-Substituted benzhydrol derivatives and a process for the preparation thereof. BE 0818801; DE 2438399; FR 2240725; GB 1478185; JP 50062959; US 4039589 . |
| 【2】 Castaner, J.; Hillier, H.; Flumecinol. Drugs Fut 1978, 3, 10, 742. |
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