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【结 构 式】 
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【药物名称】Ozagrel hydrochloride, OKY-046, Vega, Domenan 【化学名称】(E)-4-(Imidazol-1-ylmethyl)cinnamic acid monohydrochloride monohydrate 【CA登记号】78712-43-3 (anhydrous), 82571-53-7 (anhydrous free base) 【 分 子 式 】C13H15ClN2O3 【 分 子 量 】282.7291 |
【开发单位】Kissei (Originator), Ono (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Antitussives, Asthma Therapy, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Thromboxane Synthase Inhibitors |
合成路线1
The condensation of ethyl 4-(bromomethyl) cinnamate (I) with imidazole (II) by means of NaH in DMF gives ethyl 4-(1-imidazolylmethyl) cinnamate (III), which is hydrolyzed with NaOH in methanol / water, and acidified with HCl.
| 【1】 Bergstrom, S.; Carlson, L.A.; Weeks, J.R.; The protaglandins: A family of biologically active lipids. J Med Chem 1981, 24, 10, 409-412. |
| 【2】 Iizuka, K.; Akahane, K.; Kamijo, Y.; Momose, D.; Matsumoto, A.; Yukiyoshi, O. (Kissei Pharmaceutical Co., Ltd.; Ono Pharmaceutical Co., Ltd.); Imidazole derivative. DE 2923815; GB 2025946; US 4226878 . |
| 【3】 Blancafort, P.; Serradell, M.N.; Pento, J.T.; Castaner, J.; OKY-046. Drugs Fut 1983, 8, 4, 328. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 30685 | ethyl (E)-3-[4-(bromomethyl)phenyl]-2-propenoate; ethyl 4-(bromomethyl)cinnamate | C12H13BrO2 | 详情 | 详情 | |
| (II) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (III) | 30686 | ethyl (E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoate; 4-(1-Imidazolylmethyl)cinnamate | C15H16N2O2 | 详情 | 详情 |