Minaprine hydrochloride, 30038CM, Agr-1240, Alcas, Cantor, -Drug Synthesis Database

【结构式】

【药物名称】Minaprine hydrochloride, 30038CM, Agr-1240, Alcas, Cantor

【化学名称】3-(2-Morpholinoethylamino)-4-methyl-6-phenylpyridazine dihydrochloride
　　　　　　4-[2-[(4-Methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine dihydrochloride

【CA登记号】25953-17-7, 25905-77-5 (free base)

【分子式】C₁₇H₂₄Cl₂N₄O

【分子量】371.31303

【开发单位】Sanofi-synthélabo (Originator), Taisho (Licensee)

【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS

合成路线1

By condensation of 3-chloro-4-methyl-6-phenylpyridazine (I) with N-(2-aminoethyl)morpholine (II) by means of powdered Cu in refluxing n-butanol.

参考文献中间体

【1】 Laborit, H.; Pyridazine derivatives. ZA 7300671 .
【2】 Laborit, H.; Pyridazine derivatives in alleviating depressive states. CH 546769; DE 2229215; ES 403998; FR 2141697; GB 1345880; US 4169158 .
【3】 Castaner, J.; Minaprine. Drugs Fut 1977, 2, 12, 811.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33911	3-chloro-4-methyl-6-phenylpyridazine		C₁₁H₉ClN₂	详情	详情
(II)	12880	4-(2-Aminoethyl)morpholine; 2-(4-Morpholinyl)ethylamine; 2-(4-Morpholinyl)-1-ethanamine; N-(2-Aminoethyl)morpholine; N-Morpholine ethanamide	2038-03-1	C₆H₁₄N₂O	详情	详情

Extended Information