Carmofur, HCFU, Yamafur, Mifurol, -Drug Synthesis Database

【结构式】

【药物名称】Carmofur, HCFU, Yamafur, Mifurol

【化学名称】1-(N-Hexylcarbamoyl)-5-fluorouracil
　　　　　　5-Fluoro-N-hexyl-3,4-dihydro-2,4-dioxopyrimidine-1(2H)-carboxamide

【CA登记号】61422-45-5

【分子式】C₁₁H₁₆FN₃O₃

【分子量】257.26687

【开发单位】Mitsui Chemicals (Originator), Yamanouchi (Originator)

【药理作用】ONCOLYTIC DRUGS, Pyrimidine Antagonists, Thymidylate Synthase Inhibitors

合成路线1

By condensation of 5-fluorouracil (I) with n-hexylisocyanate (II) in dimethylacetamide at 50 C.

【1】 Ozaki, S.; Mizuno, H.; Mori, H.; Synthesis of 5-fluorouracil derivatives. JP 52078886 .
【2】 Ozaki, S.; Mori, H. (Mitsui Chemicals, Inc.); 1-Carbamoyl-5-fluorouracil derivatives. BE 846956; DE 2639135; FR 2330401; GB 1524640; JP 52077073; US 4071519 .
【3】 Blancafort, P.; Serradell, M.N.; Castaner, J.; Woodman, R.J.; Carmofur. Drugs Fut 1982, 7, 4, 235.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29241	5-fluoro-2,4(1H,3H)-pyrimidinedione；5-fluorouracil；5-Fluoro-2,4-pyrimidinedione;5-Fluoropyrimidine-2,4-dione	51-21-8	C₄H₃FN₂O₂	详情	详情
(II)	31942	1-isocyanatohexane; hexyl isocyanate	2525-62-4	C₇H₁₃NO	详情	详情

Extended Information