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【结 构 式】 
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【药物名称】Oxatomide, KW-4354, R-35443, Tinset 【化学名称】1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]benzimidazol-2(3H)-one 【CA登记号】60607-34-3 【 分 子 式 】C27H30N4O 【 分 子 量 】426.56635 |
【开发单位】Janssen (Originator), Formenti (Not Determined), Barrier Therapeutics (Formulation) 【药理作用】Allergic Skin Disorders, Treatment for, Antiallergic Ophthalmic Agents, Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Atopic Dermatitis, Agents for, DERMATOLOGIC DRUGS, Drugs for Allergic Rhinitis, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Urticaria, Treatment for, Mediator Release Inhibitors |
合成路线1
By condensation of 4-diphenylmethylpiperazine (I) with 1-(3-chloropropyl)-2-benzimidazolone (II) by means of Na2CO3 in refluxing 4-methyl-2-pentanone.
| 【1】 Yan, F.; et al.; Piperazine and piperidine derivative. BE 0852405; JP 61005068; ZA 7702000 . |
| 【2】 Church, M.K.; Castaner, J.; Oxatomide. Drugs Fut 1978, 3, 6, 465. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20796 | N-(Benzhydryl)piperazine; 1-Benzhydrylpiperazine; 1-(dibenzyl)piperazine | 841-77-0 | C17H20N2 | 详情 | 详情 |
| (II) | 33440 | 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one; 1-(3-Chloropropyl)benzimidazole-2-one; 1-(3-Chloropropyl)-2-benzimidazolidinone | 62780-89-6 | C10H11ClN2O | 详情 | 详情 |