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【结 构 式】 
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【药物名称】Norfloxacin, MK-0366, AM-715, Norflo, Lexinor, Baccidal, Sebercim, Noroxin, Fulgram, Barazan 【化学名称】1-Ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 【CA登记号】70458-96-7, 68077-27-0 (monoHCl) 【 分 子 式 】C16H18FN3O3 【 分 子 量 】319.33856 |
【开发单位】ISF (Originator), Istituto Biologico Chemioterapico ABC (Originator), Merck & Co. (Originator), Merck Sharp & Dohme (Originator), Kyorin (Not Determined), AstraZeneca (Licensee), Roberts (Licensee) 【药理作用】Antibacterial Drugs, Antibacterial Ophthalmic Drugs, ANTIINFECTIVE THERAPY, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, DNA Gyrase Inhibitors, DNA Topoisomerase IV Inhibitors, Quinolones |
合成路线1
By condensation of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (I) with piperazine (II) by heating at 170 C in water in a pressure tube.
| 【1】 Blancafort, P.; Sweetman, A.J.; Castaner, J.; Serradell, M.N.; AM-715. Drugs Fut 1981, 6, 8, 462. |
| 【2】 Irikura, T. (Kyorin Pharmaceutical Co., Ltd.); Piperazinyl derivs. of quinoline carboxylic acids. US 4146719 . |