Toloxatone, MD-69276, Umoril, Humoryl, Perenum, -Drug Synthesis Database

【结构式】

【药物名称】Toloxatone, MD-69276, Umoril, Humoryl, Perenum

【化学名称】5-(Hydroxymethyl)-3-(3-methylphenyl)oxazolidin-2-one

【CA登记号】29218-27-7

【分子式】C₁₁H₁₃NO₃

【分子量】207.23116

【开发单位】Delalande (Originator)

【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, MAO-A Inhibitors

合成路线1

By condensation of m-toluidine (I) and glycidol (II) in methanol to give 3-(m-toluidino)-1,2-propanediol (III), which was then cyclized by condensation with ethyl carbonate (A) by means of NaOCH3.

参考文献中间体

【1】 Douzon, C.; Fauvan, C.; Une nouvelle serie d'antidepresseurs: les derives de l'hydroxymethyl-5-oxazolidinone-2. Chimie Therapeutique 1973, 3, 324-327.
【2】 Sungurbey, K.; Castaner, J.; Toloxatone. Drugs Fut 1976, 1, 12, 569.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	17470	diethyl carbonate; diethylcarbonate	105-58-8	C₅H₁₀O₃	详情	详情
(I)	30687	3-methylphenylamine; m-toluidine	108-44-1	C₇H₉N	详情	详情
(II)	29648	2-oxiranylmethanol	556-52-5	C₃H₆O₂	详情	详情
(III)	34119	3-(3-toluidino)-1,2-propanediol		C₁₀H₁₅NO₂	详情	详情

Extended Information