【结 构 式】 |
【药物名称】Budesonide, S-1320, Pulmaxan, Pulmicort, Rhinocort, Entocort, Budenofalk, Preferid, Pulmicort turbuhaler, Budiair, Pulmaxan turbohaler, Pulmicort Topinasal, Pulmicort Respules, Inflammide, Giona Easyhaler, Miflonide, Rhinocort Aqua 【化学名称】16alpha,17alpha-(22R,S)-Propylmethylenedioxypregna-1,4-diene-11beta,21-diol-3,20-dione 【CA登记号】51333-22-3 【 分 子 式 】C25H34O6 【 分 子 量 】430.54613 |
【开发单位】AstraZeneca (Originator), Boehringer Ingelheim (Not Determined), Teijin (Not Determined), Chiesi (Formulation), CyDex (Formulation), ML Laboratories (Formulation), Orion Corp. (Formulation), Sheffield (Formulation), SkyePharma (Formulation), West Pharmace 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Drugs for Allergic Rhinitis, GASTROINTESTINAL DRUGS, Inflammatory Bowel Disease, Agents for, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Corticosteroids |
合成路线1
From 16alpha-hydroxyprednisolone (III) and n-butyraldehyde (A) in the presence of an acid catalyst. Budesonide is defined as a 1:1 mixture of the two epimers (I) and (II).
【1】 Thalen, A.; Brattsand, R.; Synthesis and antiinflammatory properties of budesonide, a new nonhalogenated glucocorticoid with high local activity. Arzneim-Forsch Drug Res 1979, 29, 11, 1687-90. |
【2】 Dharma, A.P.; Budesonide. Drugs Fut 1980, 5, 4, 179. |