Oxaprozin, Wy-21743, Xopane(as potassium), Daypro, Actirin, Alvo, Duraprox, -Drug Synthesis Database

【结构式】

【药物名称】Oxaprozin, Wy-21743, Xopane(as potassium), Daypro, Actirin, Alvo, Duraprox

【化学名称】4,5-Diphenyl-2-oxazolepropanoic acid
　　　　　　beta-(4,5-Diphenyloxazol-2-yl)propionic acid

【CA登记号】21256-18-8

【分子式】C₁₈H₁₅NO₃

【分子量】293.32515

【开发单位】Wyeth Pharmaceuticals (Originator), Pfizer (Licensee)

【药理作用】Non-Steroidal Antiinflammatory Drugs

合成路线1

The condensation of benzoin (I) with succinic anhydride (II) by heating at 120 C gives benzoin hemisuccinate (III), which is cyclized with ammonium acetate in refluxing acetic acid.

参考文献中间体

【1】 Brown, K. (Wyeth-Ayerst Laboratories); Oxazoles. GB 1206403; YU 244367; YU 249673 .
【2】 Brown, K. (Wyeth-Ayerst Laboratories); Oxazoles. US 3578671 .
【3】 Arrigoni-Martelli, E.; Castaner, J.; Oxaprozin. Drugs Fut 1978, 3, 7, 539.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24135	2-hydroxy-1,2-diphenyl-1-ethanone; benzoin	579-44-2	C₁₄H₁₂O₂	详情	详情
(II)	11291	Dihydro-2,5-furandione; Succinic anhydride	108-30-5	C₄H₄O₃	详情	详情
(III)	33528	4-oxo-4-(2-oxo-1,2-diphenylethoxy)butyric acid		C₁₈H₁₆O₅	详情	详情

Extended Information