Ibuprofen guaiacol ester, AF-2259, Benflogin, -Drug Synthesis Database

【结构式】

【药物名称】Ibuprofen guaiacol ester, AF-2259, Benflogin

【化学名称】2-Methoxyphenyl alpha-methyl-4-(isobutyl)phenylacetate
　　　　　　alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid 2-methoxyphenyl ester

【CA登记号】66332-77-2

【分子式】C₂₀H₂₄O₃

【分子量】312.41248

【开发单位】ACRAF (Originator)

【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Cyclooxygenase-1 Inhibitors, Cyclooxygenase-2 Inhibitors, Cyclooxygenase-3 Inhibitors, Non-Steroidal Antiinflammatory Drugs

合成路线1

By esterification of guaiacol (II) with 4-isobutylhydratropoyl chloride (I) by means of H2SO4.

参考文献中间体

【1】 Baiochi, L.; Silvestrini, B.; Proceso para la preparacion de p-isobutil-hidratropato de guayacol. ES 464502 .
【2】 Baiochi, L.; Silvestrini, B. (ACRAF SpA); Guaiacol p-isobutyl hydratropate. DE 2726435; FR 2357526; GB 1538636; JP 53025536; US 4134989 .
【3】 Blancafort, P.; Castaner, J.; de Angelis, L.; Serradell, M.N.; AF-2259. Drugs Fut 1980, 5, 11, 539.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32706	2-(3-isobutylphenyl)propanoyl chloride		C₁₃H₁₇ClO	详情	详情
(II)	13182	Guaiacol; 2-Methoxyphenol	90-05-1	C₇H₈O₂	详情	详情

Extended Information