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【结 构 式】 
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【药物名称】Eterobarb, RMI-16238, DMNP, EX 12-095, Antilon 【化学名称】1,3-Bis(methoxymethyl)-5-ethyl-5-phenyl-2,4,6-(1H,3H,5H)-pyrimidinetrione 【CA登记号】27511-99-5 【 分 子 式 】C16H20N2O5 【 分 子 量 】320.3482 |
【开发单位】Colgate Palmolive (Originator), MacroChem (Licensee) 【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS |
合成路线1
By reaction of sodium phenobarbital (I) with 2 mols of methyl chloromethyl ether (A) in DMF. It can also be obtained by reaction of phenobarbital (II), 2 mols of NaH, LiH, KH, LiOH or t-BuOK and 2 moles of methyl chloromethyl ether (A) in DMF.
| 【1】 Samour, C.M.; et al.; Anticonvulsants.1. Alkoxymethyl derivatives of barbiturates and diphenylhydantoin. J Med Chem 1971, 14, 3, 187. |
| 【2】 Vida, J.A. (The Kendall Company); Verfahren zur Herstellung von 5,5-disubstituierten N,N'-Dialkyloxyalkyl- oder N,N'-Dibenzyloxyalkylverbindugen der Barbitusaure. DE 2005108; FR 2033950; GB 1276387 . |
| 【3】 Samour, C.M.; et al. (The Kendall Company); Krampflosende Verbindungen. DE 1939787; ES 370220; FR 2015091; GB 1276386 . |
| 【4】 Castaner, J.; Playle, A.C.; Eterobarb. Drugs Fut 1976, 1, 6, 286. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 18319 | Chloro(methoxy)methane; Chloromethyl methyl ether | 107-30-2 | C2H5ClO | 详情 | 详情 |
| (I) | 40324 | sodium 5-ethyl-4,6-dioxo-5-phenyl-1,4,5,6-tetrahydro-2-pyrimidinolate | 57-30-7 | C12H11N2NaO3 | 详情 | 详情 |
| (II) | 40323 | 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione | 50-06-6 | C12H12N2O3 | 详情 | 详情 |
Extended Information